312 SCIENTIFIC STUDIES SUPPORTING TELOVITE

science-journals

REFERENCES

Bryan TM, Reddel RR. Telomerase, Immortality and Cancer. Today’s Life Science 1996;8(1): 26-28.

Hayflick L. Theories of biological aging. Experimental Gerontology 1985;20:145-159.

Spence AP. Biology of Human Aging, 2nd ed., Upper Saddle River, New Jersey: Prentice Hall; 1999.

Bryan TM, Reddel RR. Telomerase, Immortality and Cancer. Today’s Life Science 1996;8(1): 26-28.

Chan R, Woo J, Suen E, Leung J, Tang N. Chinese tea consumption is associated with longer telomere length in elderly Chinese men. Br J Nutr 2010;103(1):107-13.

Wang P, Zhang Z, Sun Y, Liu X, Tong T. The two isomers of HDTIC compounds from Astragali Radix slow down telomere shortening rate via attenuating oxidative stress and increasing DNA repair ability in human fetal lung diploid fibroblast cells. DNA Cell Biol 2010;29(1):33-9.

Shao L, Li QH, Tan Z. L-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts. Biochem Biophys Res Commun. 2004 Nov 12;324(2):931-6

Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X, Surdulescu GL, Swaminathan R, Spector TD, Aviv A. Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr 2007;86(5):1420-5.

Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: A molecule whose time has come? And gone? Clin Biochem 1997;30:91–113.

Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature reviews. Drug discovery 2006; 5(6):493-506.

Labinskyy N, Csiszar A, Veress G, Stef G, Pacher P, Oroszi G, Wu J, Ungvari Z. Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen. Current medicinal chemistry 2006; 13(9):989-96.

Uchiumi F, Watanabe T, Hasegawa S, Hoshi T, Higami Y, Tanuma S. The effect of resveratrol on the werner syndrome RecQ helicase gene and telomerase activity. Curr Aging Sci 2011;4(1):1-7.

Xia L, Wang XX, Hu XS, Guo XG, Shang YP, Chen HJ, Zeng CL, Zhang FR, Chen JZ. Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms. Br J Pharmacol 2008;155(3):387-94.

Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. “Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan”. Nature. 2003; 425(6954):191-6

Wood JG, Rogina B, Lavu1 S, Howitz K, Helfand SL, Tatar M, Sinclair D. “Sirtuin activators mimic caloric restriction and delay ageing in metazoans”. Nature 2004; 430(7000):686-689.

Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A “Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate.” Current Biology 2006; 16 (3):296-300.

Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006; 444(7117):337-42.

Thomas P, Wang YJ, Zhong JH, Kosaraju S, O’Callaghan NJ, Zhou XF, Fenech M. Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer’s disease. Mutat Res 2009;661(1-2):25-34.

Makpol S, Yaacob N, Zainuddin A, Yusof YA, Ngah WZ. Chlorella vulgaris modulates hydrogen peroxide-induced DNA damage and telomere shortening of human fibroblasts derived from different aged individuals. Afr J Tradit Complement Altern Med 2009;6(4):560-72.

Fenech M, Baghurst P, Luderer W, Turner J, Record S, Ceppi M & Bonassi S (2005) Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, b-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability – results from a dietary intake and micronucleus index survey in South Australia. Carcinogenesis 26:991–999.

Xu Q, Parks CG, DeRoo LA, Cawthon RM, Sandler DP, Chen H. Multivitamin use and telomere length in women. Am J Clin Nutr. 2009;89(6):1857-63.

Martin H, Uring-Lambert B, Adrian M, Lahlou A, Bonet A, Demougeot C, Devaux S, Laurant P, Richert L, Berthelot A. Effects of long-term dietary intake of magnesium on oxidative stress, apoptosis and ageing in rat liver. Magnes Res. 2008 June 21(2):124-30.

Killilea DW, Ames BN. Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts. Proc Natl Acad Sci U S A.  2008 April 15;105(15):5768-73.

Sheng Y, Pero RW, Olsson AR, et al. DNA repair enhancement by combined supplement of carotenoids, nicotinamide, and zinc. Cancer Det Prevent 1998; 22(4): 284-292.

Pero RW, Amiri A, Sheng Y, Welther M, Rich M. Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements. Phytomedicine 2005;12(4):255-63.

Ho E, Ames BN. Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappaB, and AP1 binding, and affects DNA repair in a rat glioma cell line. Proc Natl Acad Sci 2002; 99(26): 16770-16775.

 Jacob RA and Swendseid ME. Niacin, IN Present Knowledge in Nutrition, 7 th ed. Zieglar EE, Filer LJ (eds). Washington D.C.:IISI Press; 1996:184-190.

Rawling JM, Jackson TM, Driscoll ER, et al. Dietary niacin deficiency lowers tissue poly (ADP ribose) and NAD+ concentrations in fischer rats. J Nutr 1994; 124:1597-1603.

Weitberg AB. Effect of nicotinic acid supplementation in vivo on oxygen radical-induced genetic damage in human lymphocytes. Mutation Res 1989; 216:197-201.

Zhang JZ, Henning SM, Swendseid ME. Poly(ADP ribose) polymerase activity and DNA strand breaks are affected in tissues of niacin-deficient rats. J Nutr 1993; 123:1349-1355.

Han KC, Wong WC, Benzie IF. Genoprotective effects of green tea (Camellia sinensis) in human subjects: results of a controlled supplementation trial. Br J Nutr. 2011 Jan;105(2):171-9.

Whitney E, Rolfes S. Understanding Nutrition, Ninth Edition, Belmont, CA: Wadsworth/Thomson Learning; 2002.

Depeint F, Bruce WR, Shangari N, Mehta R, O’Brien PJ. Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism. Chem Biol Interact 2006;163(1-2):94-112.

Depeint F, Bruce WR, Shangari N, Mehta R, O’Brien PJ.Mitochondrial function and toxicity: role of B vitamins on the one-carbon transfer pathways. Chem Biol Interact 2006;163(1-2):113-32.

Manore MM. Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements. Am J Clin Nutr 2000 Aug;72(2 Suppl):598S-606S.

Woolf K, Manore MM. B-vitamins and exercise: does exercise alter requirements? Int J Sport Nutr Exerc Metab 2006 Oct;16(5):453-84.

Manore MM. Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements. Am J Clin Nutr 2000 Aug;72(2 Suppl):598S-606S.

 Whitney E, Rolfes S. Understanding Nutrition, Ninth Edition, Belmont, CA: Wadsworth/Thomson Learning; 2002.

 Sauberlich HE. Implications of nutritional status on human biochemistry, physiology, and health. Clin Biochem 1984; 17(2):132-42.

 Bondarev GI, Martinchik AN, Khotimchenko SA, et al. [Correlation  of  the  actual  vitamin B1, B2 and B6 consumption with the biochemical indices of their body allowance] Korreliativnaia  vzaimosviaz’ fakticheskogo potrebleniia vitaminov B1, B2 i B6 s biokhimicheskimi pokazateliami obespechennosti imi organizma. Vopr Pitan  1986; (2):34-7.

 Bogdanov NG, Bondarev GI, Piatnitskaia IN, et al. [Vitamin status of diamond cutters] Vitaminnyi status rabochikn, zaniatykh promyshlennoi obrabotkoi almazov. Vopr Pitan 1984; (2):28-31.

Vinogradov VV, Tarasov IuA, Tishin VS, et al. [Thiamine prevention of the corticosteroid reaction after surgery] Optimizatsiia tiaminom korticosteroidnoi reaktsii pri khirurgicheskikh vmeshatel’stvakh. Probl Endokrinol 1981; 27(3):11-6.

Kutsky R, Handbook of Vitamins and Hormones. New York: Van Nostrand Reinhold Company; 1973:208.

 Mukherjee SK; Adams JD Jr. The effects of aging and neurodegeneration on apoptosis-associated DNA fragmentation and the benefits of nicotinamide. Mol Chem Neuropathol 1997; 32(1-3):59-74.

Meerson FZ, Manukhina EB, Dosmagambetova RS. [Disorders of contractile function and adrenoreactivity of the portal vein in emotionally-painful stress and experimental myocardial infarct and their prevention by means of membrane protectors] Narusheniia sokratitel’noi funktsii  i adrenoreaktivnosti vorotnoi veny pri emotsional’no-bolevom stresse i eksperimental’no-bolevom stresse i eksperimental’nom infarkte miokarda i ikh preduprezhdenie s pomoshch’iu membranoprotektorov. Kardiologiia 1984; 24(4):104-8.

Meerson FZ, Pshennikova MG, Rysmendiev AZh, Vorontsova EIa. [Prevention of stress disorders of myocardial contractile function using membrane protectors] Preduprezhdenie stressornykh narushenii sokratitel’noi funktsii miokarda s pomoshch’iu membranoprotektorov. Kardiologiia 1983; 23(7):86-90.

Baldewicz T, Goodkin K, Feaster DJ, et al. Plasma pyridoxine deficiency is related to increased psychological distress in recently bereaved homosexual men. Psychosom Med 1998; 60(3):297-308.

 Teggin AF, van Niekerk JP. Manifestations and management of stress.S Afr Med J 1981;59(21):751-2.

Whitney E, Rolfes S. Understanding Nutrition, Ninth Edition, Belmont, CA: Wadsworth/Thomson Learning; 2002.

Whitney E, Rolfes S. Understanding Nutrition, Ninth Edition, Belmont, CA: Wadsworth/Thomson Learning; 2002.

Bjorkegren K, Svardsudd. Elevated serum levels of methylmalonic acid and homocysteine in elderly people. A population-based intervention study., J Intern Med 1999; 246(3):317-24.

Rasmussen K, Moller J, Lyngbak M. Within-person variation of plasma homocysteine and effects of posture and tourniquet application. Clin Chem 1999; 45(10):1850-5.

Kunz K, Petitjean P, Lisri M, et al. Cardiovascular morbidity and endothelial dysfunction in chronic haemodialysis patients: Is homocyst(e)ine the missing link? Nephrol Dial Transplant 1999; 14(8):1934-42.

Alpert MA, Homocysteine, atherosclerosis, and thrombosis. South Med J 1999; 92(9):858-65.

Bellamy MF, McDowell IF, Ramsey MW, et al. Oral folate enhances endothelial function in hyperhomocysteinaemic subjects. Eur J Clin Invest 1999; 29(8):659-62.

Woodside JV, Young IS, Yarnell JWG, et al. Antioxidants, but not B-group vitamins increase the resistance to low-density lipoprotein to oxidation: a randomised, factorial design, placebo-controlled trial. Atherosclerosis 1999; 144(2):419-27.

Bronstrup A, Hages M, Pietrzik K. Lowering of homocysteine concentrations in elderly men and women. Int J Vitam Nutr Res 1999; 69(3):187-93.

Suliman ME, Divino Filho JC, Barany P, et al.  Effects of high-dose folic acid and pyridoxine on plasma and erythrocyte sulfur amino acids in hemodialysis patients. J Am  Soc Nephrol 1999; 10(6):1287-96.

Mansoor MA, Kristensen O, Hervig T, et al. Plasma total homocysteine response to oral doses of folic acid and pyridoxine hydrochloride (vitamin B6) in healthy individuals. Oral doses of vitamin B6 reduce concentration of serum folate.  Scand J Clin Lab Invest 1999; 59(2):139-46.

Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, vitamin B-6, Folate, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy Press, 1998.

CDC (Centers for Disease Control). Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR 1992; 41 (No. RR-14).

Brody T.  Nutritional Biochemistry. 2nd ed. San Diego: Academic Press; 1999.

Linnell JC, Bhatt HR. Inherited errors of cobalamin metabolism and their management. Baillieres Clin Haematol1995;8(3):567-601.

Okuda K, Yashima K, Kitazaki T, Takara I. Intestinal absorption and concurrent chemical changes of

methylcobalamin. J Lab Clin Med 1973;81:557-567.

Whitney EN, Cataldo CB, Rolfes SR: Understanding Normal and Clinical Nutrition. Belmont, CA: Wadsworth/Thompson Learning; 2002.

Whitney EN, Cataldo CB, Rolfes SR: Understanding Normal and Clinical Nutrition. Belmont, CA: Wadsworth/Thompson Learning; 2002.

Stabler SP. Vitamin B-12.In Present Knowledge in Nutrition, 8 ed. Edited by Bowman BA Russell RM. Washington, DC: ISLI Press; 2001:230–240.

Higdon J. An Evidence-Based Approach to Vitamins and Minerals. New York: Thieme; 2003.

Jalaludin MA. Methylcobalamin treatment of Bell’s palsy. Methods Find Exp Clin Pharmacol 1995;17:539-544.

Yaqub BA, Siddique A, Sulimani R. Effects of methylcobalamin on diabetic neuropathy. Clin Neurol Neurosurg 1992;94:105-111.

Yoshioka K, Tanaka K. Effect of methylcobalamin on diabetic autonomic neuropathy as assessed by power spectral analysis of heart rate variations. Horm Metab Res 1995;27:43-44.

Nishizawa Y, Yamamoto T, Terada N, et al. Effects of methylcobalamin on the proliferation of androgen-sensitive or estrogen-sensitive malignant cells in culture and in vivo. Int J Vitam Nutr Res 1997;67:164-170.

Shimizu N, Hamazoe R, Kanayama H, et al. Experimental study of antitumor effect of methyl-B12. Oncology 1987;44:169-173.

Tsao CS, Myashita K. Influence of cobalamin on the survival of mice bearing ascites tumor. Pathology

1993;61:104-108.

Weinberg JB, Sauls DL, Misukonis MA, Shugars DC. Inhibition of productive human immunodeficiency virus-1 infection by cobalamins. Blood 1995;86:1281-1287.

. Kikuchi M, Kashii S, Honda Y, et al. Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci 1997;38:848-854.

Iwasaki T, Kurimoto S. Effect of methylcobalamin in accommodative dysfunction of eye by visual load. Sangyo Ika Daigaku Zasshi 1987;9:127-132.

Araki A, Sako Y, Ito H. Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis 1993;103:149-157.

Moriyama H, Nakamura K, Sanda N, et al. Studies on the usefulness of a long-term, high-dose treatment of methylcobalamin in patients with oligozoospermia. Hinyokika Kiyo 1987;33:151-156.

Isoyama R, Kawai S, Shimizu Y, et al. Clinical experience with methylcobalamin (CH3-B12) for male infertility. Hinyokika Kiyo 1984;30:581-586.

Uchiyama M, Mayer G, Okawa M, Meier-Ewert K. Effects of vitamin B12 on human circadian body temperature rhythm. Neurosci Lett 1995;192:1-4.

Tomoda A, Miike T, Matsukura M. Circadian rhythm abnormalities in adrenoleukodystrophy and methyl B12 treatment. Brain Dev 1995;17:428-431.

Yamada N. Treatment of recurrent hypersomnia with methylcobalamin (vitamin B12): a case report. Psychiatry Clin Neurosci 1995;49:305-307.

Ohta T, Ando K, Iwata T, et al. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep 1991;14:414-418.

Mayer G, Kroger M, Meier-Ewert K. Effects of vitamin B12 on performance and circadian rhythm in normal subjects. Neuropsychopharmacology 1996;15:456-464.

Hashimoto S, Kohsaka M, Morita N, et al. Vitamin B12 enhances the phase-response of circadian melatonin rhythm to a single bright light exposure in humans. Neurosci Lett 1996;220:129-132.

Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 2004;79(3):362-371.

Lin R, White JH. The pleiotropic actions of vitamin D. Bioessays. 2004;26(1):21-28.

Griffin MD, Xing N, Kumar R. Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annu Rev Nutr. 2003;23:117-145.

Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest. 2002;110(2):229-238.

Borissova AM, Tankova T, Kirilov G, Dakovska L, Kovacheva R. The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract. 2003;57(4):258-261.

Orwoll E, Riddle M, Prince M. Effects of vitamin D on insulin and glucagon secretion in non-insulin-dependent diabetes mellitus. Am J Clin Nutr. 1994;59(5):1083-1087.

Inomata S, Kadowaki S, Yamatani T, Fukase M, Fujita T. Effect of 1 alpha (OH)-vitamin D3 on insulin secretion in diabetes mellitus. Bone Miner. 1986;1(3):187-192.

Armas LA, Hollis BW, Heaney RP. Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004;89(11):5387-5391.

Holick MF. Vitamin D: A millenium perspective. J Cell Biochem. 2003;88(2):296-307.

Heaney RP. Long-latency deficiency disease: insights from calcium and vitamin D. Am J Clin Nutr. 2003;78(5):912-919.

Zittermann A. Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr. 2003;89(5):552-572.

Feskanich D, Willett WC, Colditz GA. Calcium, vitamin D, milk consumption, and hip fractures: a prospective study among postmenopausal women. Am J Clin Nutr. 2003;77(2):504-511.

Dhesi JK, Moniz C, Close JC, et al. A rationale for vitamin D prescribing in a falls clinic population. Age Ageing 2002;31:267-71.

Flicker L, Mead K, MacInnis RJ, et al. Serum vitamin D and falls in older women in residential care in Australia. J Am Geriatr Soc 2003;51:1533-8.

Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, et al. Effect of Vitamin D on falls: a meta-analysis. JAMA 2004;291:1999-2006.

Bischoff HA, Stahelin HB, Dick W, et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 2003;18:343-51.

Munger KL, Zhang SM, O’Reilly E, et al. Vitamin D intake and incidence of multiple sclerosis. Neurology 2004;62:60-5.

Merlino LA, Curtis J, Mikuls TR, et al. Vitamin D intake is inversely associated with rheumatoid arthritis. Arthritis Rheum 2004;50:72-7.

Blutt SE, Weigel NL. Vitamin D and prostate cancer. Proc Soc Exp Biol Med. 1999;221(2):89-98.

Giovannucci E, Liu Y, Rimm EB, et al. Prospective study of predictors of vitamin d status and cancer incidence and mortality in men. J Natl Cancer Inst 2006;98:451-9.

Hypponen E, Laara E, Reunanen A, et al. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 2001;358:1500-3.

Bertone-Johnson ER, Hankinson SE, Bendich A, et al. Calcium and vitamin D intake and risk of incident premenstrual syndrome. Arch Intern Med 2005;165:1246-52.

Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press, 1999.

Hoogendijk WJG, Lips P, Dik MG, Deeg DJH, Beekman ATF, Penninx BWJH. Depression Is Associated With Decreased 25-Hydroxyvitamin D and Increased Parathyroid Hormone Levels in Older Adults. Archives of General Psychiatry 2008; 65(5):495.

Lu L, Pan A, Hu FB, et al. Plasma 25-hydroxyvitamin D Concentration and Metabolic Syndrome among Middle-aged and Elderly Chinese. Diabetes Care 2009; Published online ahead of print, doi: 10.2337/dc09-0209.

Brehm JM, Celedon JC, Soto-Quiros ME, et al. Serum Vitamin D Levels and Markers of Severity of Childhood Asthma in Costa Rica. Am Journal Resp Crit Care Med 2009;179:765-771.

Bodnar LM, Krohn MA, Simhan HN. Maternal Vitamin D Deficiency Is Associated with Bacterial Vaginosis in the First Trimester of Pregnancy. J Nutr 2009; Published online ahead of print, 8 April 2009, doi:10.3945/jn.108.103168.

Bruno G. A Guide to Complementary Treatments for Diabetes. Garden City Park, NY: Square One Publishers; 2010.

Ahmed N, Thornalley PJ. Advanced glycation endproducts: what is their relevance to diabetic complications? Diabetes Obes Metab. 2007 May;9(3):233-45.

La Selva M, Beltramo E, Pagnozzi F, et al. Thiamine corrects delayed replication and decreases production of lactate and advanced glycation end-products in bovine retinal and human umbilical vein endothelial cells cultured under high glucose conditions. Diabetologia. 1996;39(11):1263-8.

Shangari N, Mehta R, O’brien PJ. Hepatocyte susceptibility to glyoxal is dependent on cell thiamin content. Chem Biol Interact. 2007;165(2):146-54.

McCormick DB. Vitamin B6. In: Bowman BA, Russell RM, eds. Present Knowledge in Nutrition. Vol. I. Washington, D.C.: International Life Sciences Institute; 2006:269-277.

Leklem JE. Vitamin B6. In: Machlin L, ed. Handbook of Vitamins. New York: Marcel Decker Inc; 1991:341-378.

Dakshinamurti S, Dakshinamurti K. Vitamin B6. In: Zempleni J, Rucker RB, McCormick DB, Suttie JW, eds. Handbook of Vitamins. 4th ed. New York: CRC Press (Taylor & Fracis Group); 2007:315-359.

Toney MD. Reaction specificity in pyridoxal enzymes. Archives of biochemistry and biophysics. 2005;433:279-287.

Han Y, Liu Y, Mi Q, et al. Pyridoxine improves platelet nitric oxide synthase dysfunction induced by advanced glycation end products in vitro. Int J Vitam Nutr Res. 2010 Jun;80(3):168-77.

Nakamura S, Niwa T. Pyridoxal phosphate and hepatocyte growth factor prevent dialysate-induced peritoneal damage. J Am Soc Nephrol. 2005;16(1):144-50

Higuchi O, Nakagawa K, Tsuzuki T, Suzuki T, Oikawa S, Miyazawa T. Aminophospholipid glycation and its inhibitor screening system: a new role of pyridoxal 5’-phosphate as the inhibitor. J Lipid Res. 2006;47(5):964-74

Perry IJ, Refsum H, Morris RW, et al. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet 1995;346: 1395-8.

Stampfer MJ, Malinow R, Willett WC, et al. A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians. JAMA 1992; 268:877-81.

Bostom AG, Silbershatz H, Rosenberg IH, et al. Nonfasting plasma total homocysteine levels and all-cause and cardiovascular disease mortality in elderly Framingham men and women. Arch Intern Med 1999; 159:1077-80.

Hofmann MA, Kohl B, Zumbach MS, et al. Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM. Diabetes Care. 1998;21(5):841-8.

Bin, Y. Zhi-jun, H. Hao, Z. Synergistic effects of homocysteine acid and advanced glycation end products on the apoptosis of vascular endothelial cells. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu (J Clin Rehab Tissue Eng Res). 2007;11(6):1156-1158.

Bjorkegren K, Svardsudd. Elevated serum levels of methylmalonic acid and homocysteine in elderly people. A population-based intervention study., J Intern Med 1999; 246(3):317-24.

Rasmussen K, Moller J, Lyngbak M. Within-person variation of plasma homocysteine and effects of posture and tourniquet application. Clin Chem 1999; 45(10):1850-5.

Kunz K, Petitjean P, Lisri M, et al. Cardiovascular morbidity and endothelial dysfunction in chronic haemodialysis patients: Is homocyst(e)ine the missing link? Nephrol Dial Transplant 1999; 14(8):1934-42.

Alpert MA, Homocysteine, atherosclerosis, and thrombosis. South Med J 1999; 92(9):858-65.

Bellamy MF, McDowell IF, Ramsey MW, et al. Oral folate enhances endothelial function in hyperhomocysteinaemic subjects. Eur J Clin Invest 1999; 29(8):659-62.

Woodside JV, Young IS, Yarnell JWG, et al. Antioxidants, but not B-group vitamins increase the resistance to low-density lipoprotein to oxidation: a randomised, factorial design, placebo-controlled trial. Atherosclerosis 1999; 144(2):419-27.

Bronstrup A, Hages M, Pietrzik K. Lowering of homocysteine concentrations in elderly men and women. Int J Vitam Nutr Res 1999; 69(3):187-93.

Suliman ME, Divino Filho JC, Barany P, et al.  Effects of high-dose folic acid and pyridoxine on plasma and erythrocyte sulfur amino acids in hemodialysis patients. J Am  Soc Nephrol 1999; 10(6):1287-96.

Mansoor MA, Kristensen O, Hervig T, et al. Plasma total homocysteine response to oral doses of folic acid and pyridoxine hydrochloride (vitamin B6) in healthy individuals. Oral doses of vitamin B6 reduce concentration of serum folate.  Scand J Clin Lab Invest 1999; 59(2):139-46.

Traber MG. Vitamin E. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, eds. Modern Nutrition in Health and Disease. Philadelphia: Lippincott Williams & Wilkiins; 2006:396-411.

Bruno RS, Leonard SW, Atkinson J, et al. Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation. Free Radic Biol Med. 2006;40(4):689-697.

Food and Nutrition Board, Institute of Medicine. Vitamin E. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington D.C.: National Academy Press; 2000:186-283.  HYPERLINK “http://www.nap.edu/books/0309069351/html/” \t “_top”

Traber MG. Does vitamin E decrease heart attack risk? summary and implications with respect to dietary recommendations. J Nutr. 2001;131(2):395S-397S.

Rimm EB, Stampfer MJ, Ascherio A, et al. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993; 328:1450–6.

Stampfer MJ, Hennekens CH, Manson JE, et al. Vitamin E consumption and the risk of coronary heart disease in women. N Engl J Med 1993; 328:1444–9.

Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 1996; 347:781–6

Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease. N Engl J Med 1997; 336:1216–22.

Morris MC, Beckett LA, Scherr PA, et al. Vitamin E and vitamin C supplement use and risk of incident Alzheimer disease. Alzheimer Dis Assoc Disord 1998;12:121–6.

Bruno G. Ailments & Natural Remedies. New York: Fifty-Ninth Street Bridge Publishing Corp; 2001.

Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academy Press, Washington, DC, 2001.

Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academy Press, Washington, DC, 2001.

Olson JA, Kobayashi S. Antioxidants in health and disease: Overview. Proc Soc Exp Biol Med 1992;200:245-7.

Olson JA. Benefits and liabilities of vitamin A and carotenoids. J Nutr 1996;126:1208S-12S.

Pavia SA, Russell RM. Beta-carotene and other carotenoids as antioxidants. J Am Coll Nutr 1999;18:426-33.

Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academy Press, Washington, DC, 2001.

Gerster H. Vitamin A-functions, dietary requirements and safety in humans. Int J Vitam Nutr Res 1997;67:71-90.

Futoryan T, Gilchrest BE. Retinoids and the skin. Nutr Rev 1994;52:299-310.

Hinds TS, West WL, Knight EM. Carotenoids and retinoids: A review of research, clinical, and public health applications. J Clin Pharmacol 1997;37:551-8.

Ross AC, Gardner EM. The function of vitamin A in cellular growth and differentiation, and its roles during pregnancy and lactation. Adv Exp Med Biol 1994;352:187-200.

Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academy Press, Washington, DC, 2001.

Ross AC. Vitamin A and retinoids. In: Modern Nutrition in Health and Disease. 9th Edition (edited by Shils ME, Olson J, Shike M, Ross AC). Lippincott Williams and Wilkins, New York, 1999, pp. 305-27.

Ross AC, Stephensen CB. Vitamin A and retinoids in antiviral responses. FASEB J 1996;10:979-85.

Semba RD. The role of vitamin A and related retinoids in immune function. Nutr Rev 1998;56:S38-48.

Ross DA. Vitamin A and public health: Challenges for the next decade. Proc Nutr Soc 1998;57:159-65.

Harbige LS. Nutrition and immunity with emphasis on infection and autoimmune disease. Nutr Health 1996;10:285-312.

Semba RD. The role of vitamin A and related retinoids in immune function. Nutr Rev. 1998;56(1 Pt 2):S38-48.

Semba RD. Impact of vitamin A on immunity and infection in developing countries. In: Bendich A, Decklebaum RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals. 2nd ed. Totowa: Humana Press Inc; 2001:329-346.

Semba RD. The role of vitamin A and related retinoids in immune function. Nutr Rev. 1998;56(1 Pt 2):S38-48.

Ross DA. Vitamin A and public health: Challenges for the next decade. Proc Nutr Soc 1998;57:159-65.

Harbige LS. Nutrition and immunity with emphasis on infection and autoimmune disease. Nutr Health 1996;10:285-312.

de Pee S, West CE. Dietary carotenoids and their role in combating vitamin A deficiency: A review of the literature. Eur J Clin Nutr 1996;50 Suppl 3:S38-53.

Semba RD. The role of vitamin A and related retinoids in immune function. Nutr Rev. 1998;56(1 Pt 2):S38-48.

Thurnham DI, Northrop-Clewes CA. Optimal nutrition: vitamin A and the carotenoids. Nutr Soc. 1999;58(2):449-457.

Carr AC, Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr. 1999;69(6):1086-1107.

Simon JA, Hudes ES. Serum ascorbic acid and gallbladder disease prevalence among US adults: the Third National Health and Nutrition Examination Survey (NHANES III). Arch Intern Med. 2000;160(7):931-936.

Carr AC, Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr. 1999;69(6):1086-1107.

Bruno RS, Leonard SW, Atkinson J, et al. Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation. Free Radic Biol Med. 2006;40(4):689-697.

Prinz W, Bortz R, Bregin B, Hersch M. The effect of ascorbic acid supplementation on some parameters of the human immunological defence system. Int J Vitam Nutr Res. 1977;47(3):248-257.

Vallance S. Relationships between ascorbic acid and serum proteins of the immune system. Br Med J. 1977;2(6084):437-438.

Kennes B, Dumont I, Brohee D, Hubert C, Neve P. Effect of vitamin C supplements on cell-mediated immunity in old people. Gerontology. 1983;29(5):305-310.

Panush RS, Delafuente JC, Katz P, Johnson J. Modulation of certain immunologic responses by vitamin C. III. Potentiation of in vitro and in vivo lymphocyte responses. Int J Vitam Nutr Res Suppl. 1982;23:35-47.

Jariwalla RJ, Harakeh S. Antiviral and immunomodulatory activities of ascorbic acid. In: Harris JR (ed). Subcellular Biochemistry. Vol. 25. Ascorbic Acid: Biochemistry and Biomedical Cell Biology. New York: Plenum Press; 1996:215-231.

Levy R, Shriker O, Porath A, Riesenberg K, Schlaeffer F. Vitamin C for the treatment of recurrent furunculosis in patients with imparied neutrophil functions. J Infect Dis. 1996;173(6):1502-1505.

Anderson R, Oosthuizen R, Maritz R, Theron A, Van Rensburg AJ. The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers. Am J Clin Nutr. 1980;33(1):71-76.

Prinz W, Bloch J, Gilich G, Mitchell G. A systematic study of the effect of vitamin C supplementation on the humoral immune response in ascorbate-dependent mammals. I. The antibody response to sheep red blood cells (a T-dependent antigen) in guinea pigs. Int J Vitam Nutr Res. 1980;50(3):294-300.

Feigen GA, Smith BH, Dix CE, et al. Enhancement of antibody production and protection against systemic anaphylaxis by large doses of vitamin C. Res Commun Chem Pathol Pharmacol. 1982;38(2):313-333.

Haskell BE, Johnston CS. Complement component C1q activity and ascorbic acid nutriture in guinea pigs. Am J Clin Nutr. 1991;54(6 Suppl):1228S-1230S.

Johnston CS, Cartee GD, Haskell BE. Effect of ascorbic acid nutriture on protein-bound hydroxyproline in guinea pig plasma. J Nutr. 1985;115(8):1089-1093.

Johnston CS, Kolb WP, Haskell BE. The effect of vitamin C nutriture on complement component C1q concentrations in guinea pig plasma. J Nutr. 1987;117(4):764-768.

Dahl H, Degre M. The effect of ascorbic acid on production of human interferon and the antiviral activity in vitro. Acta Pathol Microbiol Scand B. 1976;84B(5):280-284.

Sasazuki S, Sasaki S, Tsubono Y, Okubo S, Hayashi M, Tsugane S. Effect of vitamin C on common cold: randomized controlled trial. Eur J Clin Nutr. 2006;60(1):9-17.

Brody T. Nutritional Biochemistry. 2nd ed. San Diego: Academic Press; 1999.

Olson RE. Vitamin K. In: Shils M, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore: Lippincott Williams & Wilkins; 1999:363-380.

Geleijnse JM, Vermeer C, Grobbee DE, et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: The Rotterdam Study. J Nutr 2004;134:3100-5.

Beulens JW, Bots ML, Atsma F, et al. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis 2008;203(2):489-93.

Kurnatowska I, Grzelak P, Masajtis-Zagajewska A, Kaczmarska M, Stefańczyk L, Nowick Mi. The effect of vitamin K2 substitution on atherosclerosis and vascular calcification markers in non-dialyzed patients in chronic kidney disease stage 3-5. Nephrol. Dial. Transplant. 2013.28(suppl 1):i352-i357.

Westenfeld R, Krueger T, Schlieper G, et al. Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial. Am J Kidney Dis. 2012 Feb;59(2):186-95.

Gast GC, de Roos NM, Sluijs I, et al. A high menaquinone intake reduces the incidence of coronary heart disease. Nutr Metab Cardiovasc Dis. 2009 Sep;19(7):504-10.

Shearer MJ. The roles of vitamins D and K in bone health and osteoporosis prevention. Proc Nutr Soc 1997;56(3):915-937.

Booth SL. Skeletal functions of vitamin K-dependent proteins: not just for clotting anymore. Nutr Rev 1997;55(7):282-284.

Suttie JW. Vitamin K. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, eds. Modern Nutrition in Health and Disease. 10th ed. Baltimore: Lippincott Williams & Wilkins; 2006:412-425.

Shiraki M, Shiraki Y, Aoki C, Miura M. Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. J Bone Miner Res 2000;15:515-21.

Iwamoto I, Kosha S, Noguchi S, et al. A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-progestin therapy. Maturitas 1999;31:161-4.

Yonemura K, Kimura M, Miyaji T, Hishida A. Short-term effect of vitamin K administration on prednisolone-induced loss of bone mineral density in patients with chronic glomerulonephritis. Calcif Tissue Int 2000;66:123-8.

Knapen MH, Schurgers LJ, Vermeer C. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int 2007;18(7):963-972.

Cockayne S, Adamson J, Lanham-New S, et al. Vitamin K and the prevention of fractures. systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 2006;166:1256-61.

Knapen MH, Drummen NE, Smit E, Vermeer C, Theuwissen E. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013 Sep;24(9):2499-507.

Ferland G. Vitamin K. In: Bowman BA, Russell RM, eds. Present Knowledge in Nutrition. 9th ed. Volume 1. Washington, D.C.: ILSI Press; 2006:220-230.

Ferland G. The vitamin K-dependent proteins: an update. Nutr Rev 1998;56(8):223-230.

Tsaioun KI. Vitamin K-dependent proteins in the developing and aging nervous system. Nutr Rev 1999;57(8):231-240.

Maree AO, Jneid H, Palacios IF, Rosenfield K, MacRae CA, Fitzgerald DJ. Growth arrest specific gene (GAS) 6 modulates platelet thrombus formation and vascular wall homeostasis and represents an attractive drug target. Curr Pharm Des 2007;13(26):2656-2661.

Mizuta T, Ozaki I. Hepatocellular carcinoma and vitamin K. Vitam Horm 2008;78:435-42.

Tamori A, Habu D, Shiomi S, et al. Potential role of vitamin K(2) as a chemopreventive agent against hepatocellular carcinoma. Hepatol Res 2007 Sep;37 Suppl 2:S303-7.

Nimptsch K, Rohrmann S, Linseisen J. Dietary Intake of Vitamin K and Risk of Prostate Cancer in the Heidelberg Cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutr 2008;87(4):985-992.

Tortora G, Anagnostakos N. Principles of anatomy and physiology. New York: Harper & Row Publishers; 1981: 655.

Whitney E, Rolfes S. Understanding Nutrition, sixth edition. St. Paul: West Publishing, 1983:384-390.

Rules and Regulations.  Federal Register 1993; Vol. 58, No. 3, pp. 2677.

Reid IR. Pharmacological  management of  osteoporosis in postmenopausal women: a

comparative  review. Drugs & aging 1999; 15(5):349-63.

Prince R. The calcium controversy revisited: implications of new data. Medical journal of Australia 1993; 159(6):404-7.

Dawson-Hughes B. Calcium supplementation and bone loss: a review of controlled clinical trials. American journal of clinical nutrition 1991; 54(1 Suppl):274S.

Cumming RG. Calcium intake and bone mass: a quantitative review of the evidence. Calcified tissue international 1990; 47(4):194-201.

Whitney E, Cataldo C, Rolfes S. Understanding Normal and Clinical Nutrition. Belmont, California: Wadsworth Publishing; 1998: 426-433, 439-448.

Laulert L, Almeida M de A, Araujo VG, Francisco CM. [Osteoporosis: a silent epidemic which will turn public] Osteoporose:a epidemia silenciosa que devese tornar publica. Revista brasileira de enfermagem 1995; 48(2):161-7.

Wisneski LA. Clinical management of postmenopausal  osteoporosis. Southern medical journal 1992; 85(8):832-9.

Blank RD, Bockman RS. A review of clinical trials of therapies for osteoporosis using fracture as an end point. Journal of clinical densitometry 1999; 2(4):435-52.

Scheiber LB 2nd, Torregrosa L. Evaluation and treatment of postmenopausal osteoporosis. Seminars in arthritis and rheumatism 1998; 27(4):245-61.

Cumming RG, Nevitt MC. Calcium for prevention of osteoporotic fractures in postmenopausal women. Journal of bone and mineral research 1997; 12(9):1321-9.

Wark JD. Osteoporotic fractures: background and prevention strategies. Maturitas 1996; 23(2):193-207.

Tortora G, Anagnostakos N. Principles of anatomy and physiology. New York: Harper & Row Publishers; 1981: 655.

Wilson ED, Fisher KH, Garcia PA.  Principles of nutrition, fourth edition. New York: John Wiley & Sons, New York; 1979:274.

Cohen L, Laor A, Kitzes R. Magnesium malabsorption in postmenopausal osteoporosis. Magnesium 1983; 2:139-43.

Cohen L, Kitzes R. Infrared spectroscopy and magnesium content of bone mineral in osteoporotic women. Isr J Med Sci 1981; 17:1123-25.

Geinster JY, Strauss L, Deroisy R, et al. Preliminary report of decreased serum magnesium in postmenopausal osteoporosis. Magnesium 1989; 8:106-9.

Dimai H-PPorta S, Wirnsberger G, et al. Daily oral magnesium supplementation suppresses bone turnover in young adult males. J Clin Endocrinol Metab 1998; 83:2742-48.

Stendig-Lindberg G, Tepper R, Leichter I. bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnesium Res (1993) 6:155-63.

Whitney E, Cataldo C, Rolfes S. Understanding Normal and Clinical Nutrition, Fifth Edition. Belmont, California:West/Wadsworth; 1998:463-8.

Sahap Atik O. Zinc and senile osteoporosis. J Am Geriatr Soc 1983; 31:790–91.

Relea P, et al. Zinc, biochemical markers of nutrition and type 1 osteoporosis. Age Ageing (1995) 24:303–7.

Elmståhl S, et al. Increased Incidence of Fractures in Middle-aged and Elderly Men with Low Intakes of Phosphorus and Zinc. Osteoporos Int 1998; 8:333–40.

Strause L, Saltman P, Smith KT, et al. Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. J Nutr 1994; 124:1060-4.

Kaprara A, Krassas GE. Selenium and thyroidal function; the role of immunoassays. Hell J Nucl Med 2006;9(3):195-203.

Köhrle J, Jakob F, Contempré B, Dumont JE. Selenium, the thyroid, and the endocrine system. Endocr Rev 2005;26(7):944-84.

. Eaton-Evans J, McIlrath EM, Jackson WE, et al. Copper supplementation and bone-mineral density in middle-aged women. Proc Nutr Soc 1995;54:191A.

Gold M. Basketball bones. Science 1980; 80:101–2.

Raloff J. Reasons for boning up on manganese. Science News 1986;27:199.

Strause L, Saltman P, Smith KT, et al. Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. J Nutr 1994;124:1060–4.

Food and Nutrition Board, Institute of Medicine. Chromium. Dietary reference intakes for vitamin A, vitamin K, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, D.C.: National Academy Press; 2001:197-223.

Thrailkill KM, Lumpkin CK Jr, Bunn RC, Kemp SF, Fowlkes JL. Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues. Am J Physiol Endocrinol Metab 2005;289(5):E735-45.

Eckhert C. Other trace elements In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, eds. Modern Nutrition in Health and Disease. 10th ed. Philadelphia: Lippincott, Williams & Wilkins; 2006:338-350.

Bunker VW. The role of nutrition in osteoporosis. British journal of biomedical science 1994; 51(3):228-40.

Nielsen FH. Studies on the relationship between boron and magnesium which possibly effects the formation and maintenance of bones. Magnesium and trace elements 1990; 9(2):61-9.

Volpe SL, Taper LJ, Meacham S. The relationship between boron and magnesium status and bone mineral density in the human: a review. Magnesium research 1993; 6(3):291-6.

Nielson FH, Hunt CD, Mullen LM, Hunt JR. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J 1987;1:394–7.

Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: A molecule whose time has come? And gone? Clin Biochem 1997;30:91–113.

Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature reviews. Drug discovery 2006; 5(6):493-506.

Bradamante S, Barenghi L, Villa A. Cardiovascular protective effects of resveratrol. Cardiovasc Drug Rev 2004; 22(3):169-188.

Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature reviews. Drug discovery 2006; 5(6):493-506.

Higdon J. Resveratrol. Micronutrient Information Center: Linus Pauling Institute; 2005. Retrieved June 13, 2007 from http://lpi.oregonstate.edu/infocenter/phytochemicals/resveratrol/index.html#intro.

Banerjee S, Bueso-Ramos C, Aggarwal BB. Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 2002; 62(17):4945-4954.

Li ZG, Hong T, Shimada Y, et al. Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. Carcinogenesis 2002; 23(9):1531-1536.

Tessitore L, Davit A, Sarotto I, Caderni G. Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression. Carcinogenesis 2000; 21(8):1619-1622.

Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature reviews. Drug discovery 2006; 5(6):493-506.

Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature reviews. Drug discovery 2006; 5(6):493-506.

Ghanim H, et al. An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol. J Clin Endocrinol Metab 2010; Published online ahead of print, doi: 10.1210/jc.2010-0482.

Kennedy DO, et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation.  Am J Clin Nutr 2010; 91(6):1590-1597.

Omenn GS. Chemoprevention of lung cancer: the rise and demise of beta-carotene. Annu Rev Public Health 1998;19:73-99.

Erlinger TP, Guallar E, Miller ER, et al. Relationship between systemic markers of inflammation and serum beta-carotene levels. Arch Intern Med 2001;161:1903-8.

van der Vliet A. Cigarettes, cancer and the carotenoids: a continuing, unresolved antioxidant paradox. Am J Clin Nutr 2000;72:1421-3.

Green A, Williams G, Neale R, et al. Daily sunscreen applications and beta-carotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomized controlled trial. Lancet 1999;354:723-9.

Snodderly DM. Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. Am J Clin Nutr 1995;62:1448S-61S.

Hammond BR Jr, Wooten BR, Snodderly DM, et al. Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin. Optom Vis Sci 1997;74:499-504.

Yeum KJ, Ahn SH, Rupp de Paiva SA, et al. Correlation between carotenoid concentrations in serum and normal breast adipose tissue of women with benign breast tumor or breast cancer. J Nutr 1998;128:1920-6.

Butt MS, Sultan MT. Green tea: nature’s defense against malignancies. Crit Rev Food Sci Nutr 2009;49(5):463-73.

Sun AY, Wang Q, Simonyi A, Sun GY. Botanical phenolics and brain health. Neuromolecular Med 2008;10(4):259-74.

Stoner GD, Mukhtar H.  Polyphenols as cancer chemopreventive agents.  J Cell Biochem Suppl 1995; 22:169-80.

Presser A. Pharmacist’s Guide to Medicinal Herbs. Petaluma, California:Smart Publications; 2000.

Kuhn MA, Winston D. Herbal Therapy & Supplements: A Scientific & Traditional Approach. Philadelphia:Lippincott; 2000.

Mills S, Bone K. Principles and Practice of Phytotherapy: Edinburgh;Churchill Livingstone; 2000.

Blumenthal M, Goldberg A, Brinckmann J (eds). Herbal Medicine: Expanded Commission E Monographs: Newton, Massachusetts;Integrative Medicine Communications; 2000.

 Shim JS, Kang MH, Kim YH, Roh JK, Roberts C, Lee IP.  Chemopreventive effect of green tea (Camellia sinensis) amonth cigarette smokers. Cancer Epidemiol Biomakers Prev 1995; 4(4):387-391.

Mukhtar H, Ahmad N. Green tea in chemoprevention of cancer. Toxicol Sci 1999;52(2 Suppl):111–7.

Suganuma M, Okabe S, Sueoka N, et al. Green tea and cancer chemoprevention. Mutat Res 1999;428:339–44.

Menon LG, Kuttan R, Kuttan G. Anti-metastatic activity of curcumin and catechin. Cancer Lett 1999;141:159–65.

Meyer AS, Yi OS, Pearson DA, et al. Inhibition of human low-density lipoprotein oxidation in relation to composition of phenolic antioxidants in grapes (Vitis vinifera). J Agric Food Chem 1997;45:1638-43.

Freedman JE, Parker C, Li L, et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 2001;103:2792-8.

Chisholm A, Mann J, Skeaff M, et al. A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects. Eur J Clin Nutr 1998;52:12-6.

Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 1998;23:385-89.

Stein JH, Keevil JG, Wiebe DA, et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 1999;100:1050-5.

Freedman JE, Parker C, Li L, et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 2001;103:2792-8

Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 1998;23:385-89.

Lyopene monograph. Alt Med Rev 2003; 8(3): 336-342.

Lyopene monograph. Alt Med Rev 2003; 8(3): 336-342.

Levy J, Bosin E, Feldman B, et al. Lycopene is a more potent inhibitor of human cancer cell proliferation than either α-carotene or β-carotene. Nutr Cancer 1995; 24:257–66.

Lyopene monograph. Alt Med Rev 2003; 8(3): 336-342.

Kucuk O, Sarkar FH, Sakr W, et al. Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. Cancer Epidemiol Biomarkers Prev 2001; 10:861-8.

Lyopene monograph. Alt Med Rev 2003; 8(3): 336-342.

Giovannucci E. Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. J Natl Cancer Inst 1999; 91:317–3

Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.

Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203.

Schroder H, Clausen N, Ostergard E, Pressler T. Folic acid supplements in vitamin tablets: a determinant of hematological drug tolerance in maintenance therapy of childhood acute lymphoblastic leukemia. Ped Hematol Oncol 1986;3:241-7.

Froscher W, Maier V, Laage M, et al. Folate deficiency, anticonvulsant drugs, and psychiatric morbidity. Clin Neuropharmacol 1995;18:165-82.

Reynolds EH. Neurological aspects of folate and vitamin B12 metabolism. Clin Haematol 1976;5:661-96.

Reynolds EH. Folate metabolism and anticonvulsant therapy. Proc R Soc Med 1974;67:68.

Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.

Peters ML, Leonard M, Licata AA. Role of alendronate and risedronate in preventing and treating osteoporosis. Cleve Clin J Med 2001;68:945-51.

Goodman GA, Rall TW, Nies AS, Taylor P. The Pharmacological Basis of Therapeutics, 9th ed.

Sterling JB, Heymann WR. Potassium iodide in dermatology: a 19th century drug for the 21st century-uses, pharmacology, adverse effects, and contraindications. J Am Acad Dermatol 2000;43:691-7.

Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.

Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.

Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.

Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7..

John-Kalarickal J, Pearlman G, Carlson HE. New medications which decrease levothyroxine absorption. Thyroid 2007;17:763-5.

Upton R, ed. Astragalus Root: Analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia. 1999:1-25.